The invention provides an operation optimization method for a LNG (Liquefied Natural Gas) receiving station, and relates to the field of information automation. The method comprises the following steps that: obtaining the related parameter of the LNG receiving station, and triggering the working situation model module of the operation equipment of the LNG receiving station in fixed time to obtaina working condition model corresponding to each piece of equipment; constructing the integral optimal scheduling model of the LNG receiving station on the basis of each working condition model, and carrying out optimal solving on the integral optimal scheduling model of the LNG receiving station to obtain a scheduling scheme after the LNG receiving station is optimized; and on the basis of the scheduling scheme, scheduling the LNG receiving station. By use of the method, the integral optimal scheduling model of the LNG receiving station is established, on the premise of meeting the external output plane of natural gas, the optimal scheduling scheme is automatically given by taking the minimum total production cost of the operating system of the LNG receiving station as a target, the scheduling economy of the operating system of the LNG receiving station is improved, the targets of energy saving, emission reduction, cost reduction and synergy of an enterprise are realized, and the problem brought by artificial subjectivity and insufficient experience of scheduling personnel is avoided to a certain degree.