The invention discloses zero-emission system and method for high-salt cyanide wastewater. The zero-emission system includes a regulation settling tank, a micro-electrolytic tank, an electric catalyticoxidizing tank, a flocculation settling pond, a DTRO desalting device, a reverse osmosis device, etc. The zero-emission method includes steps of: electrolysis, flocculation settlement, desalting andrecovery, etc. The system and the method have the advantages as follows: cyanide organic substances in wastewater are decomposed through microelectrolysis and electrocatalytic oxidation, so that compared with the prior art, the electrochemical treatment does not introduce a large quantity of foreign elements to the system, so that concentration of soluble inorganic salts is not increased when theconcentration of organic substances in the wastewater is decreased, thereby reducing work load of the DTRO desalting device and output quantity of solid salt in evaporative crystallization. The systemand the method improve use efficiency and prolong replacement period of the DTRO; in the invention, the organic substances and inorganic salts are treated independently, so that decomposition or recovery efficiency of single component is increased, and production consumption is reduced.