The invention discloses a comprehensive management system and a comprehensive management method for blocking and inhibiting gas on working faces of coal mines. The comprehensive management system comprises air blocking walls and a spraying device. The air blocking walls are arranged on two sides of the spraying device; the air blocking walls comprise air bricks, the air bricks are connected with one another by buckles, and inflation holes and exhaust holes are formed in the air bricks; the spraying device comprises a hydraulic support, coal cutting rotary drums, liquid storage tanks, inhibition liquid pumps and spray nozzles, and the liquid storage tanks are used for being filled with inhibition liquid; the coal cutting rotary drums are arranged on a side of the hydraulic support, the spray nozzles are arranged on two sides of the hydraulic support, and the inhibition liquid pumps are arranged between the spray nozzles and the liquid storage tanks and are communicated with the spray nozzles and the liquid storage tanks via inhibition liquid transport pipelines. According to the scheme, the comprehensive management system and the comprehensive management method have the advantages that the traditional corner blocking processes are improved, the air bricks are connected with one another by the buckles to form the air blocking walls, accordingly, corners can be quickly and efficiently blocked, and the comprehensive management system can be reused; the traditional gas management technologies are innovated by processes for spraying the inhibition liquid on the working faces to inhibit gas release, and accordingly multiple inhibiting and delaying effects can be realized.