The invention provides a medicine management system having dual authentication. The medicine management system comprises a central control unit, a user log-in unit, a medicine storing unit, and a fingerprint reinspection unit. The fingerprint reinspection unit has fingerprint identification points, which are disposed at a hand-operated opening part of the medicine storing unit. The fingerprint reinspection unit conducts reinspection on the identity of a user who tends to manually open the storing unit, and determines whether the user has the right of opening the medicine storing unit. The control circuit of the storing unit unlocks the locking mechanism only when the user who currently logs in the medicine management system and the user who manually opens the medicine storing unit have theprivilege of opening the medicine storing unit. The invention is advantageous in that the security of the conventional automatic medicine management system can be effectively enhanced; the medicine loss risk caused by the stealing of users' logging-in information can be prevented; the medicine management process can be standardized, and medicine-taking efficiency can be improved.