The invention provides a long-acting insecticide composition. The long-acting insecticide composition is characterized by being prepared from, by weight, 25-35 parts of pyrethroid, 15-25 parts of nanometer gadolinium oxide hollow microspheres, 10-16 parts of alfalfa antimicrobial peptide, 3-7 parts of polyhexamethylguanidine phosphate, 6-13 parts of carboxyl betaine and 40-60 parts of edible alcohol. According to the long-acting insecticide composition, steady release of the pyrethroid in a normal temperature can be achieved, plant composition is combined, the safety is further improved, the long-acting insecticide composition is used to kill pests in space, especially used for prevention and treatment of flying pests, and has a good insecticidal effect.