The invention discloses a medical scalpel disinfection device. The medical scalpel disinfection device comprises a first support, a first disinfection box, a scalpel box, an ultraviolet generator anda base, the first disinfection box is installed in the center of the top of the base, an infrared generator is installed at the side, away from the ultraviolet generator, inside the first disinfectionbox, a high temperature steam disinfection box is installed at the top of the first disinfection box, an ultrasonic wave generator is installed at the bottom inside a ultrasonic wave washing pool through a fourth support, and a portable stainless steel washing pool is installed outside a washing pool groove opening. Through the arrangement of the high temperature steam disinfection box, the scalpel is subjected to steam disinfection at high temperature in a sealed environment; besides, through the arrangement of the ultrasonic wave washing pool, a scalpel handle is comprehensively disinfected, it is guaranteed that the scalpel works in a sterile state before an operation, and through the scalpel box and the portable stainless steel washing pool, in the whole process, the scalpel is not incontact with the outside environment.