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发明公开
CN108004216A TSPO在治疗脑胶质瘤中的应用及重组单纯疱疹病毒及其制备方法和应用 有权

TSPO在治疗脑胶质瘤中的应用及重组单纯疱疹病毒及其制备方法和应用
摘要：
本发明涉及基因工程领域，公开了一种重组单纯疱疹病毒、所述重组单纯疱疹病毒的制备方法和应用。具体地，重组单纯疱疹病毒包括载体和外源核苷酸序列，载体为缺失编码ICP34.5和ICP47的基因、以及可选的缺失编码ICP6、TK和UNG的基因中的至少一种的单纯疱疹病毒，外源核苷酸序列的插入位点为载体上缺失编码ICP34.5、ICP47、ICP6、TK和UNG的基因的位置中的至少一处；外源核苷酸序列包括具有能够降低TSPO基因表达水平的核苷酸序列。以及降低脑胶质瘤细胞中TSPO基因的表达水平在制备治疗脑胶质瘤的药物中的应用。本发明的重组单纯疱疹病毒具有良好的抗脑胶质瘤效果。
摘要（英）：

The invention relates to the field of gene engineering, and discloses a recombinant herpes simplex virus as well as a preparation method and application of the recombinant herpes simplex virus. Particularly, the recombinant herpes simplex virus comprises a carrier and an exogenous nucleotide sequence, wherein the carrier is a herpes simplex virus of at least one of a gene lacking codes ICP34.5 andICP47 and a selected gene lacking the codes ICP6, TK and UNG; an insertion site of the exogenous nucleotide sequence is at least one of positions of the genes lacking the codes ICP34.5, ICP47, ICP6,TK and UNG on the carrier; the exogenous nucleotide sequence comprises a nucleotide sequence capable of reducing the expression level of the TSPO gene. The invention also discloses application of reduction of the expression level of the TSPO gene in the brain glioma cell in preparation of medicine for treating the brain glioma. The recombinant herpes simplex virus disclosed by the invention has agood anti-brain glioma effect.

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