The invention discloses a spray drying method for improving the yield of enzyme activity. According to the invention, a windshield disk is arranged at the middle axis of a cyclone separator and a material collector and is located at the position which is 2 to 10 cm far from a feeding opening in the material collector; the windshield disk directly faces a discharging opening of the cyclone separator. Compared with the prior art, the spray drying method disclosed by the invention has the advantages of high inlet air temperature, high equipment production efficiency and short period of contact between a heat-sensitive material enzyme preparation and hot air, generally within 30s;, the yield of the enzyme activity is high which can reach 75 percent or above and the production efficiency is improved by 20 percent or above; the spray drying method has obvious spray drying effects in particular to protease preparation fermentation liquid incapable of resisting high temperature and low-cost feed enzyme preparation fermentation liquid and is also widely suitable for spray drying of heat-sensitive materials such as other enzyme preparation fermentation liquid, extracting solutions and fermentation bacteria liquid.