The invention discloses a system and methods for assessing the interior of an autonomous vehicle. According to the invention, an autonomous vehicle includes interior sensors including a camera, IR camera, electro-chemical sensor, humidity sensor, and temperature sensor. Initial and final outputs of these sensors are captured for a trip conveying one or more passengers. If changes in the outputs ofthe sensors are detected, whether the final outputs of the sensors are acceptable may be evaluated. In some embodiments, an aggregation of the outputs is evaluated and found unacceptable even where individual outputs are acceptable. Outputs may be presented to a dispatcher to confirm that the outputs are unacceptable. If the outputs are found to be unacceptable, the vehicle may be autonomously driven to a cleaning station. Personal items may be identified in camera outputs and alerts generated in response.