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发明公开
CN108025034A 乙型肝炎病毒复制的调控 有权

乙型肝炎病毒复制的调控
摘要：
本公开涉及通过使所述细胞与至少一种剂(agent)接触来调节乙型肝炎病毒(HBV)复制的方法、所述剂的筛选及其在用于治疗受试者中的HBV感染或与HBV感染相关的疾病或病症的药物中的用途，所述至少一种剂调控源自SNAI2、SOX7和其他因子组成的指定的组的至少一种因子。在一个优选的实施方案中，所述剂是来源于SOX7或SNAI2或其订书肽(stapled peptide)的一种肽。作为单独的发明，还公开了鉴定调控病毒的复制的至少一种因子的方法。
摘要（英）：

Presently disclosed is a method of modulating Hepatitis B virus (HBV) replication by contacting the cell with at least one agent that modulates at least one factor from a specified group consisting ofSNAI2 SOX7 and other factors the screening of said agent and use thereof in a medicament for treating HBV infection or disease or condition associated with a HBV infection in a subject. In one preferred embodiment the agent is one peptide derived from SOX7 or SNAI2 or stapled peptides thereof. As a separate invention a method of identifying at least one factor that modulates replication of a virus is also disclosed.

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