The invention relates to a thrombus fetching guide sheath, an inner core structure thereof and a sheath canal structure. By the aid of the thrombus fetching guide sheath, the inner core structure andthe sheath canal structure, the technical problem of influence of quick exchange connectors additionally arranged at the front ends of guide sheaths on the use of surgical instruments such as thrombusfetching catheters in the prior art can be solved. The thrombus fetching guide sheath comprises an inner core, a sheath canal and a guide wire via hole structure. The hardness of the inner core and the hardness of the sheath canal are gradually increased from the inside to the outside, the inner core is of a tubular structure with a proximal-end opening and a distal-end opening, the guide wire via hole structure is perforated through the sheath canal and distal-end side walls of the inner core, and an inner cavity of the inner core can be communicated with the outside of the sheath canal viathe guide wire via hole structure, so that a proximal end of a guide wire can extend into the distal-end opening of the inner core and extends out of the guide wire via hole structure; the guide wirevia hole structure comprises an inner core guide wire via hole and a sheath canal guide wire via hole, the inner core guide wire via hole is formed in the inner core, and the sheath canal guide wire via hole is formed in the sheath canal. The thrombus fetching guide sheath, the inner core structure and the sheath canal structure have the advantages that the guide wire via hole structure is formedin distal-end side walls of the thrombus fetching guide sheath as compared with the quick exchange connectors additionally arranged at distal ends of sheath canals in the prior art, and accordingly distal ends of follow-up thrombus fetching instruments can extend out without being affected.