The invention provides a formula with a function of simultaneously degrading aflatoxin and zearalenone. The formula is an effective and safe method for biodegrading mycotoxins. The formula has the advantages that composition conditions for bacillus licheniformis, saccharomyces cerevisiae and lactobacillus acidophilus are optimized by the aid of response surface regression designs, and the optimalAFB1 (aflatoxin 1) and ZEA (zearalenone) degradation rates can reach 45.49% and 44.90% when the volume ratio reaches 1:1:1; then the bacillus licheniformis, the saccharomyces cerevisiae and the lactobacillus acidophilus are compatible with mycotoxins degradation enzymes generated by aspergillus niger by means of fermentation, and the AFB1 and ZEA degradation rates can reach 63.95% and 73.51% whenthe volume ratio reaches 3:2 and are increased by 40.58% and 63.72% as compared with previous single composite probiotics degradation rates; as shown by test results, the formula is the effective method for simultaneously degrading the AFB1 and the ZEA which are two types of mycotoxins by the aid of the mycotoxins degradation enzymes generated by composite probiotics and the aspergillus niger by means of fermentation.