The invention discloses a production method of vanillin-1,2-propylene glycol acetal. The production method comprises the following steps: firstly, cleaning a reaction still, dehydrating the reaction still and a condensing device thereof so as to enable the water content of the reaction still to be lower than 500 ppm; secondly, adding raw materials vanillin and 1,2-propylene glycol into the reaction still; thirdly, adding an acidic substance as a catalyst into the reaction still and uniformly stirring; fourthly, vacuumizing the reaction still and enabling the reaction still to be in a certain negative pressure state; fifthly, raising the temperature of the reaction still to required temperature and reacting at the required temperature for a certain time; sixthly, carrying out sampling detection on a reaction product, adding a certain amount of alkaline raw materials into the reaction still to neutralize the catalyst after the reaction product is qualified by detecting; seventhly, carrying out reduced pressure distillation on the unreacted 1,2-propylene glycol and finally distilling and collecting to obtain qualified vanillin-1,2-propylene glycol acetal. The reaction time of the production method disclosed by the invention is 3 to 8 hours; compared with the prior production method, the production method disclosed by the invention has the advantages that reaction time is greatly shortened; in addition, the use of an organic solvent benzene is avoided and further environment friendliness is realized.