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发明授权
CN108047271B 一种槲皮素二聚体衍生物及其制备方法和应用 有权 转让

一种槲皮素二聚体衍生物及其制备方法和应用
摘要：
本发明公开了一种槲皮素二聚体衍生物或其药学可接受的水合物，包括其立体异构体或互变异构体。其制备步骤包括：槲皮素与溴丙炔在碱作用下制得7‑炔丙氧基槲皮素（II)；溴代醇与叠氮钠反应,制得叠氮醇（III)；（III)与磷酰二氯化合物作用制得（IV)；（II)和（IV)在CuSO4.5H2O/抗坏血酸钠作用下制得式（I)。本发明的槲皮素二聚体衍生物具有抗癌、抗氧化、消炎和抗突变作用。
摘要（英）：

The invention discloses quercetin dipolymer derivative or pharmaceutically acceptable aquo-complex thereof. The quercetin dipolymer derivative is prepared from stereisomer or tautomer. The quercetin dipolymer derivative is prepared by the steps: preparing 7-propynyl oxy quercetin (II) from quercetin and propargyl bromide under the alkali action; reacting bromhydrin with sodium azide to prepare alcohol azide (III); reacting the (III) with phosphoryl dichloro compound to prepare (IV); preparing a formula (I) from the (II) and the (IV) under the action of CuSO4.5H2O/sodium ascorbate. The quercetin dipolymer derivative disclosed by the invention has the anticancer, antioxidant, inflammation diminishing and antimutation effects.

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