The invention discloses a high-strength and high-conductivity CuCrZrMg series copper alloy wire. The high-strength and high-conductivity CuCrZrMg series copper alloy wire comprises the following components in percentage by mass: 1.5-15.0% of Cr, 0.1-2.5% of Zr, 0.05-1.0% of Mg and the balance being copper and inevitable impurities. In addition, the invention also discloses a preparation method ofthe high-strength and high-conductivity CuCrZrMg series copper alloy wire. The preparation method comprises the following steps: step one. carrying out fusion casting to obtain an ingot casting; steptwo. carrying out surface treatment and homogenization treatment on the ingot casting; step three. carrying out cold forging to obtain a bar, and then carrying out cold rotary forging to obtain a wire bar; and step four. drawing the wire bar to obtain the wire, and carrying out ageing treatment on the wire. The high-strength and high-conductivity CuCrZrMg series copper alloy wire has the beneficial effects that the wire is reasonable in design of the alloy components, high in alloying degree, appropriate in production cost, controllable in technology and environmentally-friendly and has highalloy strength and high electrical conductivity; and the high tensile strength and the high electrical conductivity can meet the requirements of high current connectors, electric power, machinery andelectronics and the like on high-strength and high-conductivity materials.