The invention discloses a preparation method of a roxithromycin micro-capsule preparation, which comprises the following steps of: preparation of a capsule material solution, preparation of a suspension, sedimentation and vacuum drying. The roxithromycin micro-capsule preparation is scientific in formula and strong in practicability; with the adoption of a micro encapsulation technology, an activeingredient, roxithromycin, is encapsulated in an auxiliary material for sedimentation and precipitation; the prepared roxithromycin micro-capsule preparation is 120-200um in particle size; an auxiliary capsule material covers an unpleasant odor and a taste of roxithromycin; due to the particularity of a technology, an effective part can be reserved more completely; physical properties are stable;the possibility of deterioration due to high temperature influence is low; the activity of roxithromycin in the stomach is improved; the stimulation of a drug to the stomach is reduced; roxithromycinis slowly released by the high polymer auxiliary capsule material; the detention time of the drug in a body is prolonged; and the absorptivity of the drug is improved significantly.