The invention discloses self-propelled micro-nano-oxygenation equipment. The self-propelled micro-nano-oxygenation equipment comprises a micro-nano aerating device, a walking driving device and a floating body; the walking driving device comprises a controller, a positioning device and a propelling device; the propelling device is mounted at the lower part of the floating body and controls the floating body to displace; the controller receives a signal of the positioning device and controls the propelling device to start and stop; the micro-nano aerating device cuts and refines air bubbles through turbulent flow blades to increase dissolved oxygen. The device disclosed by the invention can generate uniform high-density micro-nano-air bubbles to promote oxygen dissolution; the self-propelled micro-nano-oxygenation equipment can be controlled to move automatically, and is convenient to operate and high in adaptability.