The invention provides a refreshing wet tissue liquid medicine. The liquid medicine is prepared from components in parts by mass as follows: 10-20 parts of menthyl lactate, 1-3 parts of herba menthaeextract, 7-10 parts of rosemary hydrolat, 5-8 parts of borneol, 10-15 parts of thymus mongolicus extract, 10-15 parts of wormwood extract, 2-5 parts of an antioxidant, 5-10 parts of a solubilizer and40-60 parts of deionized water. With application of menthyl lactate, the herba menthae extract, the rosemary hydrolat, borneol, the thymus mongolicus extract and the wormwood extract to the field of disposable hygiene products, effects of cooling and refreshing are realized; menthyl lactate has durability, slight aroma of herba menthae and strong and short herba menthae cool effect; the rosemary hydrolat is mild and has cool effect and light faint scent, and unification of short-term strong cool effect and long-lasting cool effect is realized.