The invention discloses a method for managing the annulus pressure of a four-spud-in deep well. The method includes the following steps that S1, a borehole is drilled in the surface layer by 70-80 m,and a marine riser is put down and fixed; S2, during first spud-in, a drill is taken out after the borehole is drilled to the position 600-700 m below the pulp surface, a first spud-in casing pipe isput down, and cement paste is injected into annulus gaps, and returns to the pulp surface; S3, during second spud-in, the drill is taken out after the borehole is drilled to the position 1,500-1,700 mbelow the pulp surface, a second spud-in casing pipe string is put down, the cement paste is injected into the annulus, and the top is controlled to the position 30-50 m below a suspender; S4, duringthird spud-in, the drill is taken out after the drill drills into a target layer, a third spud-in casing pipe is put down, a well mouth is installed, the cement paste is injected into the annulus, and cement first pulp returns to the position 110 m below a first spud-in casing pipe shoe; the annulus above the first pulp is filled with nitrogen, and the segment length of spacer fluid between the first pulp and tail pulp is 220-230 m; S5, during fourth spud-in, the drill is taken out after the borehole is drilled to the target layer, a tail pipe string is put down, the tail pipe string is suspended on the position 150 m above a third spud-in casing pipe shoe, the cement paste is injected, and next operation is executed after the cement paste is solidified. The problem that pressure is easily generated in the annulus of the four-spud-in deep well is solved.