The invention provides an array substrate, a manufacturing method thereof, a touch display panel and a display device. The array substrate comprises a substrate body, touch electrodes and electrode wires, the touch electrodes are positioned on the substrate body, and the electrode wires are connected with the touch electrodes and made of nano-silver. As the surface drag of the nano-silver is small, the nano-silver has strong electrical conductivity, is transparent and can replace metal wires in the prior art, wires of a border area are nano-silver wires, ink formed on a cover plate to cover the wires is omitted, the display device with the array substrate can be made into a frameless display device, and requirements of users are met.