The invention discloses a method for refining a Shuanghuanglian preparation by using a membrane separation technology. The method comprises the following steps: A. preparing water extract: weighing honeysuckle flower, radix scutellariae and fructus forsythiae according to a prescription, and carrying out water extraction on the weighed materials for later use; B. refining by a ceramic membrane: adding the water extract into a ceramic membrane device for continuously filtering, and collecting filtrate, wherein the pore sizes of a filtration membrane of the ceramic membrane device are 400-500nm;C. directly using the filtrate obtained in the step B as liquid medicine to leave factory, or taking the filtrate as a raw material to prepare extract, tablet, powder, granules, injection and suppository. The treatment method provided by the invention enables the efficacy of the original Shuanghuanglian water extract to be effectively improved; in particular, the 450nm film determined by means ofseries of research and development has the best comparative advantages and practical effects in terms of parameters such as extract yield, chlorogenic acid content, baicalin content, forsythin content, membrane flux and interception performance.