The invention discloses a method for preparing a thread anti-seizure coating by adopting an unbalanced magnetron sputtering technology. The method comprises the steps of 1, polishing and cleaning bolts; 2,carrying out a sand blasting treatment on the bolts; 3, arranging a Ni target, a Ag target and a Pd target on a plurality of independent targets on an unbalanced magnetron sputtering device, theunbalanced magnetron sputtering technology is adopted on the surface of the bolts to obtain a depositional Ni transition layer; 4, and adopting the unbalanced magnetron sputtering technology to continuously deposit an AgPd coating on the depositional Ni transition layer, and finally the thread anti-seizure coating is formed by the depositional Ni transition layer and the AgPd coating. According to the invention, the problem of seizure failure occurring in the dismounting and locking processes of bolts is solved, and the Ag in the AgPd coating located on the surface layer has good ductility and lubricity, and the heat stability of the coating is improved after the Pd is added, meanwhile, the AgPd composite coating has good oxidation resistance and relatively high hardness, so that the comprehensive performance of the coating is improved.