The invention discloses a traditional Chinese medicine compound composition for treating liver injury. The traditional Chinese medicine compound composition contains the following components in partsby weight: 20-30 parts of herba portulacae, 15-30 parts of cortex albiziae, 15-20 parts of raw malts, 5-10 parts of radix glycyrrhizae preparat, 10-20 parts of caulis perillae and 15-20 parts of poria. Besides, the invention further provides a preparation method and application of the traditional Chinese medicine compound composition. The traditional Chinese medicine compound composition is simplein constitution, reasonable in proportion, capable of obviously alleviating the symptoms such as inappetence, fatigue, abdominal distension, eructation, nausea, emesis, weight lose, hepatic-region orupper right abdomen distension and dull pain occurring during liver injury, and the fat accumulation of the liver is obviously reduced. The traditional Chinese medicine compound composition has a good treatment effect after being taken for a long time, has no any side effect and is convenient to take, and a very good choice is provided for vast liver injury patients.