The invention discloses an optimized load shedding method with consideration of the influence of a distributed power supply. All nodes in a distribution network upload interruptible load capacities ata current time and load priority levels to a centralized controller at a root node and the centralized controller establishes an optimized load shedding model with consideration of an outer net equivalence according to the uploaded information and a flow restraint; the centralized controller converts a non-linear flow restraint into one in a convex second-order cone mode by means of second-ordercone relaxation and thus calculates an optimized load shedding value with consideration of the distributed power supply output influence rapidly, and issues the information to all node control units;after all nodes perform a load shedding action, a measuring unit monitors whether the node voltages are restored to be in a rated range and determines whether to complete the load shedding process. With the method disclosed by the invention, quick and precise load shedding controlling is realized in a distribution network including lots of distributed power supplies and the voltage of the distribution network is restored to the greatest extent; limit exceeding of the voltage of the distributed power supply is avoided; and thus over-voltage tripping of the distributed power supply caused by theimproper load shedding is avoided.