The invention discloses compositions, and provides a method for preventing and/or treating depression by using the compositions, and applications of the compositions in preparing medicines for preventing and/or treating depression. The compositions contain cannabidiol, a 5-HT2A receptor antagonist, and a 5-HT reuptake inhibitor or medicinal salt thereof, and also can comprise one or more medicinalcarriers or excipients, wherein the use amount of cannabidiol and the use amount of the 5-HT2A receptor antagonist and the 5-HT reuptake inhibitor or the medicinal salt thereof enable the effect of the composition to be superior to that obtained when the medicines with the corresponding dosages are independently used.