The invention discloses a material guiding eccentric adjusting device for production of a waterproof cloth, and belongs to the technical field of production of the waterproof cloth. A through groove is formed in a top part of a front side wall of a first rack; a fixing block is arranged in an inner cavity of the through groove; a connection rod is arranged on an outer side wall of the fixing block; the other end of the connection rod is movably connected to the first rack; the fixing block is connected with a material guiding roll through a first bearing; the other end of an adjusting shaft penetrates through a protection box, extends to the inner cavity of the second rack and is connected with a first bevel gear; a V-groove is formed in the top of the second rack; a V-shaped bearing rackis arranged in the V-groove; a bearing block is arranged on a bottom of the V-shaped bearing rack; a bottom of the bearing block is connected with an adjusting screw rod through a second bearing; anda second bevel gear which is matched with the first bevel gear is arranged on the adjusting screw rod. The material guiding eccentric adjusting device is simple in structure design and convenient in use; smoothness of conveying of the waterproof cloth by the material guiding roll can be ensured; continuous connection of a blank base can be ensured safely and smoothly; and batch production is facilitated.