A rotating dental floss pick which is convenient and easy to operate, capable of cleaning teeth without damage and capable of achieving thorough cleaning without dead angles between adjacent surfacesis disclosed. The rotating dental floss pick is formed by separating an operating end from a holding end in a conventional dental floss pick. The operating end is formed by connecting floss, a bow anda fixed handle. The holding end consists of a rod, a fixing sleeve, a screw shaft, a steel wire, baffle screws and a screw sleeve. When the fixed handle of the operating end is inserted into the fixing sleeve of the holding end, a needed angle is adjusted, and the screw sleeve is rotated to transmit force so as to drive the steel wire to extend forward to fasten the fixed handle, and then the rotating dental floss pick can be operated. The operating end can be dismounted by rotating the screw sleeve in an opposite direction to allow the steel wire to retract backward to loosen the operating end. The operating end is disposable and the holding end is applied for long term.