The invention provides a design and manufacturing method of a large-scale inlaying type hot-forging mold. The mold includes a mold sleeve and a mold core; and the mold sleeve is a universal tooling and is formed by casting of low-cost special cast steel, and the mold core consists of a plurality of inserts inlaid together. After the mold sleeve and the inserts are designed, the base plane and thepositioning plane of the mold sleeve, and the positioning plane and positioning keyways of the inserts are firstly subjected to finish machining; and the positioning keyways are accurately installed to realize the positioning between the inserts, countersunk head screws are used for achieve that the inserts and the mold sleeve are fixed in the vertical direction, then the fastening between the inserts and the mold sleeve is achieved by a one-or-multi-stage standardized bottom plate and a wedge-shaped pressing plate auxiliary mechanism, and the large-scale inlaying hot-forging mold is finally obtained. The low-cost cast steel mold sleeve and the multi-insert inlaying type mold structure are adopted, the manufacturing cycle is shortened and the manufacturing cost is reduced, the forming requirement of integrated hot mold forging of large projection area components can be met at the same time, smaller insert sizes also have the advantages of better processing accuracy, heat treatment hardness, and replaceability, and the life of the large-scale hot-forging mold can be effectively improved.