The invention discloses a pipeline cleaning robot system. The system comprises a climbing locomotive and a control unit, wherein the climbing locomotive comprises a walking component and a cleaning component, the walking component comprises a walking climbing boot and a supporting climbing boot; the cleaning component comprises a water spraying pipe and a brush; the control unit is connected witha stretchable drive and a walking drive through a control line to realize a walking of the climbing locomotive; the control unit controls the water spraying pipe to spray cleaning agent to the innerwall of the pipeline, the brush is controlled to rotate to clean the inner wall of the pipeline. According to the pipeline cleaning robot system, no matter how the diameter size of the pipeline or thechannels inside the pipeline is different in size, the pipeline cleaning robot can realize all-direction and convenient cleaning; the cleaning agent can be dynamically replaced according to a dirt type inside the pipeline, no matter what the dirt is dust, the oil liquid or some other stubborn stains can be cleaned and can be thoroughly cleaned; a brush motor drives the brush to rotate after the pipe is cleaned to wipe a residual cleaning agent in the pipeline, and the production operation link of the pipeline can be quickly recovered.