The invention discloses a driving device of a liquid crystal display and a resetting method of the driving device. The driving device of the liquid crystal display comprises a microprocessor, a time sequence controller, a switch circuit and a power supply management unit, the microprocessor is used for outputting a reset signal, outputting a power supply signal, and transmitting the LVDS signal, sending a reset inquiry instruction and receiving a feedback signal corresponding to the reset inquiry instruction; the time sequence controller is used for receiving and converting the LVDS signal, and is used for receiving a reset query instruction and sending a feedback signal corresponding to the reset query instruction; the microprocessor is used for outputting a reset signal to enable the time sequence controller to reset when the microprocessor works, and sending the reset inquiry instruction to the time sequence controller so as to determine whether the time sequence controller finishesresetting, and reset signals are reset when the time sequence controller is not reset by the microprocessor. By means of the mode, the problem of failure of reset of the time sequence controller is effectively avoided, and meanwhile the problems of abnormal display in the screen opening process are avoided.