The invention discloses a homogenization emulsification machine, which comprises an emulsification tank, a material outlet is arranged at the bottom portion of the emulsification tank, a rotation shaft is arranged in the emulsification tank, and is provided with multiple layer stirring paddles, stirring steel wires are connected between the stirring paddles, the emulsification tank is provided with a water phase inlet and an oil phase inlet, the water phase inlet and the oil phase inlet are oppositely arranged, and are respectively provided with a pressurization pump, the emulsification tank is provided with a gas suction hole and an emulsifier inlet, a vacuum pump is connected to the gas suction hole, and the emulsifier inlet is provided with a flow rate valve. According to the present invention, the liquids form the fine particles by impacting the pressurized liquids so as to greatly increase the contact area of the liquids, such that the water phase liquid and the oil phase liquid are uniformly mixed so as to substantially improve the emulsification quality.