The invention discloses a mobile orthopedic Kirschner wire positioning guide device. The device comprises an operation platform, a lifting unit, a steering unit and a guide sleeve; the operation platform is made of ferromagnetic materials, the lower end of the lifting unit is provided with a base cooperatively fixed with the operation platform, and a horizontal driving shaft is connected to the base through a bearing; the base is internally provided with a strong magnetic system, the strong magnetic system comprises fixed magnetic steel and rotary core magnetic steel arranged in the driving shaft, the driving shaft is connected with a handle, the handle drives the rotating shaft to rotate, and through different polarities or the same polarity of the rotary core magnetic steel and the fixedmagnetic steel, different attraction forces are generated on the operation platform to fix or release the base; the lifting unit comprises a lower shell body, an upper shell body, a battery arrangedin the lower shell body, a circuit board, a motor, a speed reducer, a screw rod and a lifting nut, and the screw rod and the nut are in matched screw connection with each other; the device is suitablefor fixing a Kirschner wire inserted in various directions to prevent the Kirschner wire from deviation when the Kirschner wire penetrates into the human body.