The invention discloses an explosion-proof bridge crane provided with isolating frames. The explosion-proof bridge crane comprises a crane body and the isolating frames. Fixing base frames are arranged on the two sides of the crane body, rail beams are arranged at the upper ends of the fixing base frames, an explosion-proof main beam is slidably connected between the rail beams on the two sides, and the lower end of the explosion-proof main beam is slidably connected with a hoisting trolley. The outer side of the hoisting trolley is horizontally connected with four telescopic frames, and the lower ends of the telescopic frames are vertically connected with the isolating frames. Each isolating frame comprises a fixed frame and a movable frame, wherein the lower end of the fixed frame is connected with the movable frame, and the movable frame is slidably guided out of the fixed frame or guided into the fixed frame. Fireproof fabric is arranged on the inner end faces of the isolating frames. In this way, when hoisted flammable and combustible hazardous articles explode, the isolating frames are erected outside a combustion point to form an isolating zone to retard outward spreading offires, and workers can be evacuated in time.