The invention discloses a cyclical crushing device for a biological drug kit. The cyclical crushing device comprises a crushing box support, wherein a crushing box is mounted at the upper end of the crushing box support; a first motor is mounted in the middle of the upper end of the crushing box and is connected with a crushing rod through a rotating shaft; crushing cones are mounted on inner walls of the two sides of the crushing box; a second motor is mounted on the outer surface of the crushing box and is connected with a driving gear on the outer side of the crushing box through rotating shafts; driven gears are both arranged at the two ends of the driving gear; the rotating shaft of the driving gear and the rotating shafts of the driven gears are connected with crushing cutters in aninner cavity of the crushing box; an inclined filtering screen plate is mounted on the lower side of the crushing cutters; a cyclical crushing inlet is formed in the lowest part of the inclined filtering screen plate; and a spiral conveyor is arranged on one side of the cyclical crushing inlet. The cyclical crushing device for the biological drug kit has the advantages that a structure is reasonable, and cyclical crushing on the biological drug kit is carried out, so that a crushing effect is more obvious.