The invention relates to a motor tilting and rotation locking mechanism and an unmanned aerial vehicle. The motor tilting and rotation locking mechanism comprises a driving rocker arm, a first transmission assembly, a driven wheel, a second transmission assembly and a locking rod, wherein the driving rocker arm has a locking position; the driving rocker arm respectively drives the driven wheel andthe locking rod to rotate through the first transmission assembly and the second transmission assembly; when the driving rocker arm is in the locking position, the locking rod prevents the driven wheel from rotating in the reverse direction through a position limiting locking part; when the driving rocker arm leaves the locking position, before the driven wheel is driven to rotate by the drivingrocker arm, the locking rod is driven to be disengaged from the locking part by the driving rocker arm. The motor tilting and rotation locking mechanism has the technical effects that the motor inclination and rotation can be realized; the inclination and rotation of the motor in the same direction in the work process can be prevented.