The invention relates to a manufacturing method of batryticated silkworm handmade medical soap. The batryticated silkworm handmade medical soap consists of the following active component raw materialsin parts by weight: 60 to 70 parts of transparent soap base, 8 to 10 parts of white batryticated silkworm, 8 to 10 parts of radix angelicae, 8 to 10 parts of rhizoma typhonii, 8 to 10 parts of radixasparagi, 7 to 10 parts of beewax, 0.5 to 1 part of natural essence and 10 to 15 parts of olive oil. The manufacturing method comprises the following steps: drying the white batryticated silkworm in the sun, grinding the white batryticated silkworm into powder and mixing the white batryticated silkworm powder with clean water to form paste; triturating the radix angelicae and the rhizoma typhonii,cooking for 30 to 40 minutes, filtering and taking clear liquid; putting the transparent soap base into a container, heating and dissolving; pouring the white batryticated silkworm paste, the clear liquid, the bee white wax, the olive oil and the natural essence, and stirring uniformly to obtain mixed liquid; and pouring the mixed liquid into a mold and performing solidification to obtain the white batryticated silkworm handmade medical soap. The medical soap manufactured by the method provided by the invention has antibacterial and anti-inflammation effects, is used for removing spots and fading spots, has obvious anti-ageing effect, and enables skin to be soft, smooth, white and beautiful.