The invention discloses a medical drug box device. An upper installing block and a lower installing block are arranged on the left side of the upper end face of a drug box and the left side of the lower end face of the drug box in a matched mode, a storage cavity is formed in the drug box, and a second fastening hole is formed in the left end wall of the storage cavity; the upper end of the rightend face of the drug box is provided with a hollow groove with an end port facing right, and a first inclined groove is formed in the left end wall of the hollow groove; a rotating cavity extending forwards and backwards is arranged in the top wall of the storage cavity, and a lower through connecting hole is formed between the rotating cavity and the storage cavity; an upper through connecting hole which communicates with the rotating cavity and the first inclined groove is formed in the upper end of the rotating cavity, and a sliding groove which is extended up and down and communicates withthe hollow groove is formed in the right side of the rotating cavity; a through connecting groove is formed between the sliding groove and the rotating cavity, and a tooth-shaped wheel is rotatably arranged in the through connecting groove through a first rotating pin shaft; and a rotating column is arranged in the rotating cavity in a rotatable mode.