The invention belongs to the technical field of building construction, and discloses a test method for wind-induced internal pressure of a building with openings to avoid the effect of air column resonance. The test method comprises the steps of when the test sampling frequency is 331 Hz, the sampling time is 61.8 seconds, and the total volume after compensation is different times of the originalvolume, verifying the existence of an air column resonance phenomenon; forming partition openings of different sizes to compare and analyze the adverse effect of the air column resonance on the measurement of the pulsating internal pressure; determining the height of a volume compensation box by the calculation of the air column resonance frequency; determining the length and width of the compensation box according to the similar law of internal pressure and the principle that the compensation box is "deep and narrow", ensuring that the air column resonance frequency is in a high frequency region of an internal pressure power spectral density curve, and reducing the effect of the air column resonance energy on the pulsating internal pressure. The calculation formula of the air column resonance frequency of an internal pressure model cavity is introduced through a complex compressor piping system, and the size of the volume compensation box is determined in advance to avoid the adverseeffect of the air column resonance and directly increase the peak response of the internal pressure.