The invention discloses a high-pressure water beam generating device and a water guide laser system. The high-pressure water beam generating device comprises a jet uniformization module, a nozzle andlight-transmitting glass. The outer side of the jet uniformization module is connected with a water pipe joint and the jet uniformization module receives water flowing from the water pipe joint and transports the water to a water outlet after uniformly distributing the water in the water pipe joint. The nozzle is installed at the water outlet to eject the water at the water outlet to form a high-pressure water beam. The light-transmitting glass is installed at the rear of the nozzle, and lasers enter the high-pressure water beam after passing through the light-transmitting glass. The water guide laser system is provided with the high-pressure water beam generating device. In this way, the jet uniformization module uniformly distributes the water transported in the water pipe joint and thentransports the water, so that the internal water pressure is uniformly distributed, the shaking phenomenon caused by the centralized distribution of the water pressure is eliminated, the processing precision and the processing efficiency are improved greatly, and the processing time is greatly shortened.