The invention discloses a zooming focusing compensation method and device of a ball dome camera; a current object distance required by current zooming focusing of the ball dome camera, a current position of a zooming motor and a current vertical field angle are acquired; focusing motor position offset corresponding to the current object distance, the current position of the zooming motor and the current vertical field angle is determined; and zooming focusing compensation is carried out according to the focusing motor position offset, so as to improve the focusing effect of the ball dome camera in the zooming focusing process and improve image definition.