The invention discloses a comprehensive treatment method of transformer substation noise. At present, it is urgent to solve the problem that noise at sensitive points of a transformer substation plantboundary and a functional area exceeds the standard. The comprehensive treatment method of the transformer substation noise comprises the steps that different modes of sound insulation barriers are built according to the relative positions between a transformer in a transformer substation and a plant boundary enclosing wall as well as the transformer in the transformer substation and a sensitivebuilding; different modes of sound insulation barriers are built according to the relative positions between an electric reactor in the transformer substation and the plant boundary enclosing wall aswell as the electric reactor in the transformer substation and the sensitive building; sound absorbing louvers are additionally mounted at an air outlet of an air exhausting fan of a heat exchanging system and an air outlet of an air conditioner external unit in the transformer substation; and under the premise that the safety distance is ensured, a forest belt with evergreen coniferophyte and broad leaved plants is planted along the periphery of the interior of the plant boundary enclosing wall, wherein the evergreen coniferophyte and the broad leaved plants are planted alternately. Accordingto the comprehensive treatment method of the transformer substation noise, comprehensive treatment is carried out in a targeted mode according to the characteristic of the noise of equipment in the transformer substation, the noise generated by the equipment can be effectively reduced, and it is ensured that the noise at the sensitive points of the transformer substation plant boundary and the surrounding functional area reaches the national standard.