The invention discloses a synthetic method of a tetramethylthiuram disulfide drug intermediate. The synthetic method comprises the following steps: adding a dimethylamine solution and a sodium nitratesolution into a reaction container, controlling the solution temperature to be 20 to 24 DEG C, controlling the stirring speed to be 230 to 260 rpm, adding a 1-pentanethiol solution, adding a thiophane solution in batches within 30 to 50 min, and continuously reacting for 80 to 120 min; then adding nickel bromide powder, controlling the solution temperature to be 15 to 18 DEG C, adding lead tetraacetate, continuously reacting for 2 to 4 h, standing for 30 to 50 min, adding a potassium chloride solution, layering the solution to separate an oil layer, washing with a 2-heptanone solution for 20to 40 min, carrying out recrystallization in a 1-chloropropane solution, and carrying out dehydration of a dehydrating agent so as to obtain the finished product tetramethylthiuram disulfide.