The invention relates to a tobacco, water and fertilizer integrated dynamic nutrition management method suitable for Yunnan mountainous regions. The method comprises steps as follows: 7 days after transplantation, water and fertilizer integrated equipment is adopted to perform pure water drop irrigation with application amount being 4-5 m<3>/mu; 15 days after transplantation, organic water-solublefertilizer with application amount being 3-5 kg/mu is applied to 5-6 m<3>/mu water for drop irrigation; 25 days after transplantation, the organic water-soluble fertilizer with application amount being 5-7 kg/mu is applied to 5-6 m<3>/mu water for drop irrigation; 35 days after transplantation, the organic water-soluble fertilizer with application amount being 7-10 kg/mu is applied to 6-8 m<3>/muwater for drop irrigation; 45 days after transplantation, the organic water-soluble fertilizer with application amount being 15-18 kg/mu is applied to 8-15 m<3>/mu water for drop irrigation; 60 daysafter transplantation, the organic water-soluble fertilizer with application amount being 3-6 kg/mu and potassium sulfate with application amount being 0-2.88 kg/mu are applied to 6-8 m<3>/mu water for drop irrigation. With adoption of the method, water and fertilizer utilization rate can be effectively increased, nitrogen reducing amount reaches 15%-20%, tobacco quality is improved, the purposesof saving water and fertilizer, reducing cost and improving quality are achieved, and one new method is provided for scientific tobacco planting.