The invention belongs to the technical field of medical instruments and discloses a resuscitation bag pressing device. The device comprises a fixing rack, a mechanical arm and an execution mechanism,wherein the mechanical arm is detachably connected with the fixing rack, the executing mechanism is fixed at the end of the mechanical arm, and the execution mechanism comprises a driving device, a fixing device and a pressing device; the fixing device is used for fixing a resuscitation bag, and the driving device is connected with the pressing device and is used for driving the pressing device topress the resuscitation bag from the two sides. The invention further discloses an oxygen supply system which is used for controlling the resuscitation bag pressing device. The resuscitation bag is fixed to the execution mechanism, and the execution mechanism presses the resuscitation bag through the pressing device, so that the operation of manually pressing the resuscitation bag by hand in traditional rescue work is replaced, and the rescue efficiency is improved; moreover, a mechanical pressing mode is used, so that the pressing frequency and the pressing pressure are stable and can well fit with the respiratory frequency of a patient, and a good rescue effect is achieved.