The invention provides a centering positioning device for pile splicing, applies to prestressed concrete pipe piles and aims at solving pile splicing problems of the prestressed concrete pipe piles inactual use. Datum platforms are arranged firstly and adjusted by instruments such as a leveling rod and the like, and levelness of the datum platforms is guaranteed; then a lower pipe pile is fixed by a fixator I and fixed at positioning screw holes of the corresponding datum platform, screw lifters are mounted, levelness of an upper pipe pile is adjusted by combination of lifting platforms and fixators II connected with the upper pipe pile, the datum platforms are then connected with a centering positioner through inclined struts, finally, position of the upper pipe pile is adjusted precisely through the centering positioner, complete centering connection of the upper pipe pile and the lower pipe pile is realized, vertical perpendicularity is calibrated, and the problems that upper and lower pipe piles in splicing of prefabricated pipe piles are not aligned easily and whole pile body deflects after pile sinking are solved effectively.