The invention relates to a calculation method of reasonable delay time of single-hole-interval millisecond vibration-absorbing blasting of an electronic detonator. The method comprises the following steps: acquiring tunnel surrounding rock density and longitudinal wave propagation speed cP; measuring plane geometry parameters of each blast hole; calculating the diameter, the blast depth and the charge coefficient of each blast hole; calculating the time for stress wave arriving at the closest free face after a blasting cartridge in each blast hole blasts; calculating the time t2n for a crack,arriving at an excavating face, of each blast hole in the blast hole length direction; calculating the time t3m for a prism object throwing to reach the distance of 10cm from a new free face, whereinthe prism object is encircled by the blasting cartridge in each blast hole after blasting; calculating the total delay time of the electronic detonator in each blat hole; calculating blasting seismicperiod Tn of assisting holes and surrounding holes under different charge mass; setting the delay time of the electronic detonator in each blast hole based on the calculation result; and adjusting thedelay time of each blast hole based on the field blasting test and the monitoring result. With the adoption of the method, good ore crushing effect is ensured; the blasting vibration is greatly absorbed; the social benefit and the economic benefit are high.