The invention discloses polyfluoro-substituted aryl biheterocyclic derivatives with a structure as shown in a general formula I or I' and optical isomers thereof, or pharmaceutically acceptable saltsor solvates thereof, or pharmaceutically acceptable salts or solvates of the optical isomers. The general formula I or I' are described in the specification; and in the general formula I or I', at least one of R1 and R2 is a fluorine atom, and at least two selected from a group consisting of Rc, Rd, Re and Rf are fluorine atoms. The invention also discloses application of pharmaceutical compositions containing the polyfluoro-substituted aryl biheterocyclic derivatives and application of the polyfluoro-substituted aryl biheterocyclic derivatives to preparation of antitumor drugs. Results of multiple experiments prove that the derivatives provided by the invention have substantial inhibitory effect on Akt1 and shows strong propagation inhibition activity against tumor cell lines such as human ovarian cancer cell lines, colon cancer cell lines and prostatic cancer cell lines. Therefore, the derivatives of the invention can be applied as Akt inhibitors to drugs used for treating solid tumors or blood cancer associated with cell proliferation of human beings or animals.