The invention discloses a micro-nano structure array heat dissipation surface and a preparation method thereof. The heat dissipation surface comprises a heat dissipation substrate and an array structure which is constructed on the surface of the heat dissipation substrate and formed by cones composed of a fluorine-containing polymer and heat conducting particles. The heat dissipation surface can greatly increase the effective heat exchange area, the surface roughness and the heat conducting coefficient, facilitates the transfer of heat to a fluorine-containing working medium, facilitates nucleate boiling of the fluorine-containing working medium, can strengthens a wetting ability of the fluorine-containing working medium for the heat dissipation surface, improves the critical heat flux density and plays a role of strengthening phase change heat transfer. The preparation method comprises the steps of uniformly stirring and mixing a fluorine-containing polymer emulsion, the heat conducting particles, a solvent, an auxiliary and the like to obtain slurry, printing the slurry on the surface of the heat dissipation substrate through a silk-screen printing process, drying to remove the solvent, then performing thermal treatment in the protective atmosphere, enabling the fluorine-containing polymer resin to be solidified on the surface of the heat dissipation substrate, and obtaininga heat dissipation surface with a micro-nano structure array. The preparation steps are easy and easy to implement, and scale production is easy to be realized.