The invention discloses a diagnosis method of information system and equipment performance in a power system. The diagnosis method is used for intelligent diagnosing a running condition of an information system. A self-adaptive integrated learning model based on a fault diagnosis expert system and a recurrent neural network is constructed by collecting running information of the information system, related equipment and an intermediate, the running fault of the information system can be quickly and intelligently diagnosed, so that system running maintainer can timely troubleshoot the abnormity, and the business quality of service is improved.