The invention discloses a data centralized pre-processing method integrating multiple measurement and control devices and belongs to the field of development of smart transformer substation operationnew technology. According to the invention, through collection of measurement values collected in a distributed manner and pre-treatment of each measurement value in different precision levels, integration of different measurement and control devices of a smart transformer substation is realized. Through integration in functional aspects of the different measurement and control devices of the smart transformer substation, a problem of repeated collection of local measurement control values can be solved effectively. At the same time, the utilization rate of local measurement and control devices is improved, and the construction cost of the measurement and control devices of the smart transformer substation is reduced.